Title
RNA-Puzzles Round V: Blind predictions of 23 RNA structures
Authors
[ 1 ] Instytut Informatyki, Wydział Informatyki i Telekomunikacji, Politechnika Poznańska | [ P ] employee
Scientific discipline (Law 2.0)
Year of publication
2025
Published in
Article type
scientific article
Publication language
english
Keywords
EN
- 3D structure
- aptamer
- modeling
- prediction
- riboswitch
- ribozyme
Abstract
EN RNA-Puzzles is a collective endeavor dedicated to the advancement and improvement of RNA 3D structure prediction. With agreement from structural biologists, RNA structures are predicted by modeling groups before publication of the experimental structures. We report a large-scale set of predictions by 18 groups for 23 RNA-Puzzles: 4 RNA elements, 2 Aptamers, 4 Viral elements, 5 Ribozymes, and 8 Riboswitches. We describe automatic assessment protocols for comparisons between prediction and experiment. Our analyses reveal some critical steps to be overcome to achieve good accuracy in modeling RNA structures: identification of helix-forming pairs and of non-Watson-Crick modules, correct coaxial stacking between helices and avoidance of entanglements. Three of the top four modeling groups in this round also ranked among the top four in the CASP15 contest.
Date of online publication
02.12.2024
Pages (from - to)
399 - 411
License type
CC BY-NC-ND (attribution - noncommercial - no derivatives)
Open Access Mode
czasopismo hybrydowe
Open Access Text Version
final published version
Date of Open Access to the publication
at the time of publication
Ministry points / journal
200
Impact Factor
36,1 [List 2023]
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