Title
Bioactive Glass Doped with Zinc Ions as a Carrier for 6-Mercaptopurine
Authors
[ 1 ] Instytut Technologii i Inżynierii Chemicznej, Wydział Technologii Chemicznej, Politechnika Poznańska | [ 2 ] Wydział Technologii Chemicznej, Politechnika Poznańska | [ 3 ] Instytut Fizyki, Wydział Inżynierii Materiałowej i Fizyki Technicznej, Politechnika Poznańska | [ S ] student | [ SzD ] doctoral school student | [ P ] employee
Scientific discipline (Law 2.0)
Year of publication
2025
Article type
scientific article
Publication language
english
Keywords
EN
- 6-mercaptopurine · Bioactive glass · Zinc · Drug delivery system · Anticancer therapy · Controlled release
Abstract
EN 6-Mercaptopurine (6MP) commonly occurs in the treatment for acute lymphoblastic leukemia in children. The drug faces several limitations related to low bioavailability and short half-life. In order to overcome the drawbacks of conventional therapeutic systems for 6MP, innovative drug delivery systems are sought. The drug contains sulfur atoms capable of forming coordination bonds with metal ions, e.g., zinc. Hence, this study presented a bioactive glass doped with zinc ions as a carrier for 6MP. The research has demonstrated the carrier’s ability to sorption and then desorption as a controlled release. The drug is evenly distributed, suggesting that the doses released from it will always be similar. Drug release in a neutral environment is prolonged at controlled doses, while in an acidic environment, it is immediate. The viability of MCF-7 cells was significantly inhibited when treated with bioactive glass doped with zinc and 6MP. The results indicate the high potential of the material for use in targeted anticancer therapy.
Date of online publication
04.06.2025
Pages (from - to)
9543 - 9564
License type
CC BY (attribution alone)
Open Access Mode
czasopismo hybrydowe
Open Access Text Version
final published version
Date of Open Access to the publication
at the time of publication
Ministry points / journal
70
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