Simulation of microimages emitted by virtual array of testing oligonucleotides
[ 1 ] Instytut Elektroniki i Telekomunikacji (IEt), Wydział Elektryczny, Politechnika Poznańska | [ P ] employee
2002
paper
english
- virtual objects
- modeling and simulation
- fluorometry
- DNA sequence analysis
EN This paper is concerned with utilization of virtual reality in biomeasurements. Presented questions have focused on predicting changes in the virtual optical response as a result of simulated changes in a considered DNA sequence composition. Relationships between thermodynamic and optical properties of a given sequence are taken in considering a light-directed library of testing oligonucleotides. The oligonucleotides embedded in the library volume make the array of short known sequences that are assumed as the testers. Simulated microimages entitled by a virtual array correspond to the sites where hybridization process is performed as a result of the DNA sequence base pairing characteristics. Presented simulation refers to changes in fluorescence signals to be sensed from the lighting array made by pixels, which intensities depend on parameters of the objects located in particular array sites.
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