The Effect of Otilonium Bromide on Quality of Human Life
[ 1 ] Wydział Inżynierii Środowiska i Energetyki, Politechnika Poznańska | [ SzD ] doktorant ze Szkoły Doktorskiej
2023
rozdział w monografii naukowej
angielski
- otilonium bromide
- irritable bowel syndrome
- cationic surfactants
- drugs
EN Otilionium bromide (OB) is a quaternary ammonium compound which is commonly known in pharmaceutical industry. It affects the distal gastrointestinal tract as an antispasmodic agent which is used by patients with irritable bowel syndrome (IBS). The drug's action is based on the inhibition of L-type and T-type calcium channels. Around 15% of the Western population struggles with IBS. OB is characterized by weak systematic absorption, which may prevent other negative impact on organism. There have been several successful treatments worldwide using OB and placebo. These medical trials have proven to be safe and successful in patients with irritable bowel syndrome. The medication reduces abdominal pain, boiling sensation and relieves discomfort better than placebo. The effects of using OB are long-lasing, even after dosing is stopped. Studies have shown that treatment with OB bromide improves quality of life. This article describes the mechanism of action, synthesis, pharmacological effects of OB and aspects in which OB improves a person's quality of life.
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