Cyclodextrine vs D-glucose in the Solutions of the Derivative of 1,4-DHP
2019
scientific article
english
- Cyclodextrin
- α-D-glucose
- Nimodipine
- ultrasounds
- host-guest complexes
EN Hydrophilic and hydrophobic cyclodextrins (CDs) have found a lot of applications in medicine pharmacology, food processing and cosmetology. They can function as a drug carrier material and parent host molecules, increasing drug biocompatibility, optimizing the efficiency of drug activity, and controlling drug release at the desired level. The effectiveness of CD complexation depends on many factors such as the type and the size of both the CD molecule itself and the guest molecule, pH of the solution, and temperature. In aqueous solution of glucose the aggregation of molecules can occur leading to the formation of CD-like structures. In the paper the possibility of the formation of the inclusion complexes of CD and glucose with Nimodipine was investigated with the aid of ultrasonic spectroscopy. By comparing the efficiency of industrial saccharides and glucose in the formation of the inclusion complexes the cost effectiveness of the use of glucose as a substitute for CD can be determined.
2019110-1 - 2019110-8
CC BY (attribution alone)
public
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