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Antimicrobial and Virucidal Potential of Morpholinium-Based Ionic Liquids


[ 1 ] Instytut Technologii i Inżynierii Chemicznej, Wydział Technologii Chemicznej, Politechnika Poznańska | [ P ] employee

Scientific discipline (Law 2.0)

[7.6] Chemical sciences

Year of publication


Published in

International Journal of Molecular Sciences

Journal year: 2023 | Journal volume: vol. 24 | Journal number: iss. 2

Article type

scientific article

Publication language


  • ionic liquids
  • antibacterial agents
  • antiviral activity
  • enzyme activity

EN Witnessed by the ongoing spread of antimicrobial resistant bacteria as well as the recent global pandemic of the SARS-CoV-2 virus, the development of new disinfection strategies is of great importance, and novel substance classes as effective antimicrobials and virucides are urgently needed. Ionic liquids (ILs), low-melting salts, have been already recognized as efficient antimicrobial agents with prospects for antiviral potential. In this study, we examined the antiviral activity of 12 morpholinium based herbicidal ionic liquids with a tripartite test system, including enzyme inhibition tests, virucidal activity determination against five model viruses and activity against five bacterial species. The antimicrobial and enzymatic tests confirmed that the inhibiting activity of ILs corresponds with the number of long alkyl side chains and that [Dec2Mor]+ based ILs are promising candidates as novel antimicrobials. The virucidal tests showed that ILs antiviral activity depends on the type and structure of the virus, revealing enveloped Phi6 phage as highly susceptible to the ILs action, while the non-enveloped phages PRD1 and MS2 proved completely resistant to ionic liquids. Furthermore, a comparison of results obtained for P100 and P001 phages demonstrated for the first time that the susceptibility of viruses to ionic liquids can be dependent on differences in the phage tail structure.

Date of online publication


Pages (from - to)

1686-1 - 1686-16




License type

CC BY (attribution alone)

Open Access Mode

open journal

Open Access Text Version

final published version

Release date


Date of Open Access to the publication

at the time of publication

Full text of article

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Ministry points / journal


Impact Factor

5,6 [List 2022]

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