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Carbimazole - synthesis and structural analysis of the tiamazole derivative


[ 1 ] Instytut Technologii i Inżynierii Chemicznej, Wydział Technologii Chemicznej, Politechnika Poznańska | [ SzD ] doctoral school student | [ P ] employee

Scientific discipline (Law 2.0)

[7.6] Chemical sciences

Year of publication


Chapter type

chapter in monograph / paper

Publication language


  • carbimazole
  • methimazole
  • prodrugs
  • hyperthyroidism
  • synthesis

EN Carbimazole is a prodrug compound whose main function, in the human body, is to inhibit the overproduction of thyroid hormones of various origins. Its active form is thiamazole, which is formed upon precise delivery to the intended organ. Therefore, this paper attempts to comprehensively describe the efficient organic synthesis of the prodrug with its proposed reaction mechanism and to analyse its spatial structure using chromatographic and spectroscopic methods, verifying the data available in the literature. The work aims to better understand the chemistry of carbimazole in order to take greater advantage of its therapeutic capabilities, but also to be a starting point for further development efforts in the context of its modified derivatives.

Pages (from - to)

15 - 24


The Book of Articles, National Scientific Conferences 2023

Presented on

National Scientific Conference “e-Factory of Science” IX edition, 15.04.2023

Open Access Mode


Open Access Text Version

final published version

Date of Open Access to the publication

at the time of publication

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