Carbimazole - synthesis and structural analysis of the tiamazole derivative
[ 1 ] Instytut Technologii i Inżynierii Chemicznej, Wydział Technologii Chemicznej, Politechnika Poznańska | [ SzD ] doctoral school student | [ P ] employee
chapter in monograph / paper
EN Carbimazole is a prodrug compound whose main function, in the human body, is to inhibit the overproduction of thyroid hormones of various origins. Its active form is thiamazole, which is formed upon precise delivery to the intended organ. Therefore, this paper attempts to comprehensively describe the efficient organic synthesis of the prodrug with its proposed reaction mechanism and to analyse its spatial structure using chromatographic and spectroscopic methods, verifying the data available in the literature. The work aims to better understand the chemistry of carbimazole in order to take greater advantage of its therapeutic capabilities, but also to be a starting point for further development efforts in the context of its modified derivatives.
15 - 24
final published version
at the time of publication