Multifunctional therapeutics in the fight against diseases of civilization - tri-element prodrugs
[ 1 ] Wydział Technologii Chemicznej, Politechnika Poznańska | [ 2 ] Instytut Technologii i Inżynierii Chemicznej, Wydział Technologii Chemicznej, Politechnika Poznańska | [ SzD ] doktorant ze Szkoły Doktorskiej | [ P ] pracownik
PL Wielokierunkowe terapeutyki w walce wobec chorobom cywilizacyjnym - proleki trójelementowe
2023
abstrakt
angielski
- tri-element prodrugs
- piwampycilin
- cDDP
- disease of civilization
- specific therapy
EN From the 19th century, the sudden increase in the prevalence of diseases forced the search for solutions that were initially only supposed to eliminate the side effects of selected diseases. With the development of medicine and pharmacy, research on innovative therapeutics began, which in a precise and strictly defined way was supposed to remove the problem in the morphological or physiological scope. The answer is prodrug therapies, which rely on the introduction of a derivative of the active substance, which undergoes biotransformation in the target organ. Tri-element prodrugs, otherwise known as tripartite prodrugs, consist of several potential medicinal substances. They can act as poisoning, stimulating cell growth, enzymatic blocking or accelerating intercellular transport. A large part of them is used in the prevention of cancer, due to the possibility of close interaction of the therapeutic with DNA molecules.
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