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Article

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Title

Circulating non-coding RNA in type 1 diabetes mellitus as a source of potential biomarkers – an emerging role of sex difference

Authors

[ 1 ] Instytut Informatyki, Wydział Informatyki i Telekomunikacji, Politechnika Poznańska | [ P ] employee

Scientific discipline (Law 2.0)

[2.3] Information and communication technology

Year of publication

2024

Published in

Biochemical and Biophysical Research Communications

Journal year: 2024 | Journal volume: vol. 736

Article type

scientific article

Publication language

english

Keywords
EN
  • Type 1 diabetes mellitus
  • Circular RNA
  • Long non-coding RNA
  • microRNA
  • Biomarkers
Abstract

EN Non-coding RNAs (ncRNAs), such as microRNA, long non-coding RNA, and circular RNA, are considered essential regulatory molecules mediating many cellular processes. Moreover, an increasing number of studies have investigated the role of ncRNAs in cancers and various metabolic disorders, including diabetes mellitus. Interestingly, some circulating ncRNA detected in body fluids may serve as novel biomarkers. There is still a lack of conventional biomarkers that detect the early stage of type 1 diabetes mellitus. Many circulating microRNA, long non-coding RNA, and circular RNA show aberrant expression in type 1 diabetes patients compared to healthy individuals. However, most studies have focused on circulating microRNA rather than long non-coding RNA or circular RNA. In addition, a few studies have evaluated sex differences in ncRNA biomarkers. Therefore, this article summarises current knowledge about circulating ncRNAs as potential biomarkers for type 1 diabetes and explores the effects of sex on such biomarkers.

Date of online publication

31.07.2024

Pages (from - to)

150482-1 - 150482-7

DOI

10.1016/j.bbrc.2024.150482

URL

https://www.sciencedirect.com/science/article/pii/S0006291X24010180?via%3Dihub

Comments

Article Number: 150482

License type

CC BY-NC-ND (attribution - noncommercial - no derivatives)

Open Access Mode

czasopismo hybrydowe

Open Access Text Version

final published version

Date of Open Access to the publication

in press

Ministry points / journal

100

Impact Factor

2,5 [List 2023]

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