The Effects of Various Food Products on Bisphosphonate’s Availability
[ 1 ] Instytut Technologii i Inżynierii Chemicznej, Wydział Technologii Chemicznej, Politechnika Poznańska | [ 2 ] Physiolution GmbH, Walther-Rathenau-Straße 49 a, 17489 Greifswald, Germany | [ P ] employee
2022
scientific article
english
- bisphosphonates
- gastrointestinal absorption
- drug bioavailability
EN The bioavailability of orally administered bisphosphonates is very low (<1%) due to their short absorption window in the proximal duodenum and high affinity for food. Food ingredients are able to bind the drug, but the presence of food extends the residence time of bisphosphonates in the absorption window. Therefore, the main goal of this study is to select a group of food products that are characterized by low binding affinity to bisphosphonates and thus will not reduce their availability upon concomitant administration. For this purpose, a combination of three methods was applied: (1) evaluation of sorption capacity for rows of digested food samples in a simulated intestinal environment; (2) evaluation of drug availability in simulated chyme; and (3) evaluation of drug availability using a simulating needle device. The results indicate that food products such as egg white and white bread are most suitable for consumption during oral bisphosphonate intake.
27.03.2022
717-1 - 717-9
Article number: 717
Article number: 717
CC BY (attribution alone)
open journal
final published version
27.03.2022
at the time of publication
public
100
5,4