Designing polymeric drug delivery systems - polymer prodrugs
[ 1 ] Instytut Technologii i Inżynierii Chemicznej, Wydział Technologii Chemicznej, Politechnika Poznańska | [ SzD ] doctoral school student | [ P ] employee
2023
chapter in monograph / paper
english
- polymer prodrugs
- polymer-drug conjugate
- hyperbranched polymer
- HPMA
EN Prodrugs are inactive derivatives of active substances of therapeutic importance, which undergo biotransformation at the target site of the in vivo system, realizing their therapeutic potential. The combination of such a compound with a polymer chain makes it possible to obtain a polymer prodrug with a varied spatial structure and therapeutic effect. Currently, these types of compounds are used as a revolutionary group of anticancer drug carriers, but their design is burdened with many requirements in terms of bioavailability and biocompatibility, which future synthetic approaches must consciously meet.
47 - 56
other
final published version
at the time of publication
public
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