RNA tertiary structure prediction using RNAComposer in CASP15
[ 1 ] Institute of Computing Science, Poznan University of Technology, Poznan, Poland | [ 2 ] Instytut Informatyki, Wydział Informatyki i Telekomunikacji, Politechnika Poznańska | [ P ] employee
2023
scientific article
english
- 2D structure tuning
- 3D structure refinement
- hierarchical fragment assembly
- homologous modeling
- RNA 3D structure prediction
- RNAComposer
EN As CASP15 participants, in the new category of 3D RNA structure prediction, we applied expert modeling with the support of our proprietary system RNAComposer. Although RNAComposer is primarily known as an automated web server, its features allow it to be used interactively, for example, for homology-based modeling or assembling models from user-provided structural elements. In the paper, we present various scenarios of applying the system to predict the 3D RNA structures that we employed. Their combination with expert input, comparative analysis of models, and routines to select representative resultant structures form a ready-for-reuse workflow. With selected examples, we demonstrate its application for the in silico modeling of natural and synthetic RNA molecules targeted in CASP15.
24.08.2023
1790 - 1799
100
2,9 [List 2022]