Zinc-doped hydroxyapatite as a pH responsive drug delivery system for anticancer drug 6-mercaptopurine
[ 1 ] Wydział Technologii Chemicznej, Politechnika Poznańska | [ 2 ] Instytut Fizyki, Wydział Inżynierii Materiałowej i Fizyki Technicznej, Politechnika Poznańska | [ 3 ] Instytut Technologii i Inżynierii Chemicznej, Wydział Technologii Chemicznej, Politechnika Poznańska | [ SzD ] doktorant ze Szkoły Doktorskiej | [ P ] pracownik
2024
artykuł naukowy
angielski
- 6-mercaptopurine
- drug delivery
- hydroxyapatite
- pH-responsive
- zinc
EN 6-Mercaptopurine (6MP) is commonly used in the treatment of acute lymphoblasticleukemia as an important agent in maintenance therapy. Despite its therapeutic ben-efits, 6MP has some limitations during therapy. Taking into account the disadvan-tages during 6MP therapy, there is a great need to create an appropriate deliverysystem for this drug. 6MP contains in its structure nitrogen and sulfur atoms capableof forming coordination compounds with metal ions, for example zinc. Therefore, inthis work, we prepared biocompatible hydroxyapatite (HAp) doped with zinc ions,and used it as a carrier for 6MP. Doped HAp has not been used as a carrier for thisdrug before. The work proved that the prepared carrier-drug system has a particlesize of about 130 nm, which indicates its potential for intravenous delivery. In addi-tion, in an acidic environment (imitating cancer cells), the carrier agglomerates allowtargeted release of the drug. The drug is evenly distributed, which indicates that thedoses released from it will always be comparable. The release of the drug in a neutralenvironment is long-lasting in controlled doses, whereas in an acidic environment it isimmediate. The obtained results indicate the high potential of the material in bothslow-release and cancer-targeted release of 6MP.
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