Drug distribution evaluation using FT-IR imaging on the surface of a titanium alloy coated with zinc titanate with potential application in the release of drugs for osteoporosis

Mariusz Sandomierski; Marcel Jakubowski; Maria Ratajczak; Adam Voelkel

doi:10.1016/j.saa.2022.121575

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Tytuł

Drug distribution evaluation using FT-IR imaging on the surface of a titanium alloy coated with zinc titanate with potential application in the release of drugs for osteoporosis

Autorzy

Mariusz Sandomierski (WTCH) ^{[ 1 ][ 7.6 ][ P ]}
Marcel Jakubowski (WTCH) ^{[ 1 ][ S ]}
Maria Ratajczak (WILiT) ^{[ 2 ][ 2.7 ][ P ]}
Adam Voelkel (WTCH) ^{[ 1 ][ 7.6 ][ P ]}

^{[ 1 ]} Instytut Technologii i Inżynierii Chemicznej, Wydział Technologii Chemicznej, Politechnika Poznańska | ^{[ 2 ]} Instytut Budownictwa, Wydział Inżynierii Lądowej i Transportu, Politechnika Poznańska | ^{[ P ]} pracownik | ^{[ S ]} student

Dyscyplina naukowa (Ustawa 2.0)

[2.7] Inżynieria lądowa i transport
[7.6] Nauki chemiczne

Rok publikacji

2022

Opublikowano w

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Rocznik: 2022 | Tom: vol. 281

Typ artykułu

artykuł naukowy

Język publikacji

angielski

Słowa kluczowe

EN

Zinc titanate
Risedronate
Drug carrier
Drug release
Osteoporosis

Streszczenie

EN The drugs most commonly used in the treatment of osteoporosis are bisphosphonates. This disease results in low mineral density and a weakened bone microstructure. The delivery methods for these drugs have many disadvantages, and new ones are being searched for. In this work, biocompatible zinc titanate coated titanium implants were obtained as potential new carriers for drugs. Such a material will release the drug, and it will have antibacterial properties. Gradual release of the bisphosphonate will have a positive effect on the recovery process and osteointegration. In addition, the drug will be released around the affected bones. The effectiveness of the modification and attachment of the drug was confirmed by SEM, XPS, EDS, FT-IR imaging, and UV–VIS. It was shown that the risedronate could be almost completely released upon contact with body fluids within a week. The drug is evenly distributed over the entire surface of the alloy as confirmed by FT-IR imaging. The results presented in this work will allow for the preparation of endoprostheses that release the drug and have antibacterial properties.

Data udostępnienia online

02.07.2022

Strony (od-do)

121575-1 - 121575-8

DOI

10.1016/j.saa.2022.121575

URL

https://doi.org/10.1016/j.saa.2022.121575

Uwagi

Article number: 121575

Typ licencji

CC BY (uznanie autorstwa)