Zeolites with Divalent Ions as Carriers in the Delivery of Epigallocatechin Gallate
[ 1 ] Instytut Technologii i Inżynierii Chemicznej, Wydział Technologii Chemicznej, Politechnika Poznańska | [ 2 ] Instytut Budownictwa, Wydział Inżynierii Lądowej i Transportu, Politechnika Poznańska | [ P ] employee | [ S ] student
[2.7] Civil engineering, geodesy and transport[7.6] Chemical sciences
2023
scientific article
english
- zeolite
- epigallocatechin gallate
- drug delivery
- controlled release
EN Epigallocatechin gallate (EGCG) is a compound with very high therapeutic potential in the treatment of osteoporosis and cancer. The disadvantages of this compound are its low stability and low bioavailability. Therefore, carriers for EGCG are sought to increase its use. In this work, new carriers are proposed, i.e., zeolites containing divalent ions of magnesium, calcium, strontium, and zinc in their structure. EGCG is retained on the carrier surface by strong interactions with divalent ions. Due to the presence of strong interactions, EGCG is released in a controlled manner from the carrier-ion-EGCG drug delivery system. The results obtained in this work confirm the effectiveness of the preparation of new carriers. EGCG is released from the carriers depending on the pH; hence, it can be used both in osteoporosis and in the treatment of cancer. The divalent ion used affects the sorption and release of the drug. The obtained results indicate the great potential of the proposed carriers and their advantage over the carriers described in the literature.
5322 - 5331
CC BY (attribution alone)
czasopismo hybrydowe
final published version
at the time of publication
140
5,4