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Article

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Title

Zeolites with Divalent Ions as Carriers in the Delivery of Epigallocatechin Gallate

Authors

[ 1 ] Instytut Technologii i Inżynierii Chemicznej, Wydział Technologii Chemicznej, Politechnika Poznańska | [ 2 ] Instytut Budownictwa, Wydział Inżynierii Lądowej i Transportu, Politechnika Poznańska | [ P ] employee | [ S ] student

Scientific discipline (Law 2.0)

[2.7] Civil engineering, geodesy and transport
[7.6] Chemical sciences

Year of publication

2023

Published in

ACS Biomaterials Science & Engineering

Journal year: 2023 | Journal volume: vol. 9 | Journal number: iss. 9

Article type

scientific article

Publication language

english

Keywords
EN
  • zeolite
  • epigallocatechin gallate
  • drug delivery
  • controlled release
Abstract

EN Epigallocatechin gallate (EGCG) is a compound with very high therapeutic potential in the treatment of osteoporosis and cancer. The disadvantages of this compound are its low stability and low bioavailability. Therefore, carriers for EGCG are sought to increase its use. In this work, new carriers are proposed, i.e., zeolites containing divalent ions of magnesium, calcium, strontium, and zinc in their structure. EGCG is retained on the carrier surface by strong interactions with divalent ions. Due to the presence of strong interactions, EGCG is released in a controlled manner from the carrier-ion-EGCG drug delivery system. The results obtained in this work confirm the effectiveness of the preparation of new carriers. EGCG is released from the carriers depending on the pH; hence, it can be used both in osteoporosis and in the treatment of cancer. The divalent ion used affects the sorption and release of the drug. The obtained results indicate the great potential of the proposed carriers and their advantage over the carriers described in the literature.

Pages (from - to)

5322 - 5331

DOI

10.1021/acsbiomaterials.3c00599

URL

https://pubs.acs.org/doi/epdf/10.1021/acsbiomaterials.3c00599

License type

CC BY (attribution alone)

Open Access Mode

czasopismo hybrydowe

Open Access Text Version

final published version

Date of Open Access to the publication

at the time of publication

Ministry points / journal

140

Impact Factor

5,8 [List 2022]

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