The Deposition of Hydroxyapatite Particles Within an Organic Matrix on the Surface of Poly(lactic acid)

Katarzyna Dopierała; Emilia Krok; Ewa Stachowska; Jagoda Nowak-Grzebyta; Walczak Krzysztof; Jacek Andrzejewski; Krystyna Prochaska

doi:10.3390/ijms252111587

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Title

The Deposition of Hydroxyapatite Particles Within an Organic Matrix on the Surface of Poly(lactic acid)

Authors

Katarzyna Dopierała (WTCH) ^{[ 1 ][ 7.6 ][ P ]}
Emilia Krok (WIMiFT) ^{[ 2 ][ 2.8 ][ P ]}
Ewa Stachowska (WIM) ^{[ 3 ][ 2.5 ][ P ]}
Jagoda Nowak-Grzebyta
Walczak Krzysztof ^{[ S ]}
Jacek Andrzejewski (WIM) ^{[ 4 ][ 2.8 ][ P ]}
Krystyna Prochaska (WTCH) ^{[ 1 ][ 7.6 ][ P ]}

^{[ 1 ]} Instytut Technologii i Inżynierii Chemicznej, Wydział Technologii Chemicznej, Politechnika Poznańska | ^{[ 2 ]} Instytut Fizyki, Wydział Inżynierii Materiałowej i Fizyki Technicznej, Politechnika Poznańska | ^{[ 3 ]} Instytut Technologii Mechanicznej, Wydział Inżynierii Mechanicznej, Politechnika Poznańska | ^{[ 4 ]} Instytut Technologii Materiałów, Wydział Inżynierii Mechanicznej, Politechnika Poznańska | ^{[ P ]} employee | ^{[ S ]} student

Scientific discipline (Law 2.0)

[2.5] Biomedical engineering
[2.8] Materials engineering
[7.6] Chemical sciences

Year of publication

2024

Published in

International Journal of Molecular Sciences

Journal year: 2024 | Journal volume: vol. 25 | Journal number: iss. 21

Article type

scientific article

Publication language

english

Keywords

EN

hydroxyapatite
poly(lactic acid)
Langmuir–Blodgett
implant
surface modification

Abstract

EN Hydroxyapatite (HAP) is a well-established material in biomedical applications, especially for bone tissue regeneration, dental implants, and drug delivery systems. Recent research emphasizes enhancing the biocompatibility and osteoconductivity of orthopedic implants using HAP. This study explores the potential of combining HAP with a lipid matrix to improve the surface properties and biocompatibility of poly(lactic acid) (PLA)-based, 3D-printed, resorbable bone implants. We utilized the Langmuir–Blodgett method to deposit HAP within a dihexadecyl phosphate (DHP) matrix onto PLA substrates. This study demonstrates that DHP and HAP form stable monolayers at the air/water interface with HAP particles distributed within a homogeneous lipid matrix. The presence of HAP and the resulting changes in surface free energy (SFE) are hypothesized to enhance the biocompatibility of PLA implants. Our findings indicate that films composed of DHP + HAP 5:1 are particularly effective in altering PLA surface characteristics, potentially improving osteointegration, and reducing microbial adherence. Overall, this work highlights that surface modification of PLA with HAP and lipid matrices is the first step towards new, promising, and cost-effective strategies for developing advanced biomaterials for bone regeneration.

Date of online publication

29.10.2024

Pages (from - to)

11587-1 - 11587-13

DOI

10.3390/ijms252111587

URL

https://doi.org/10.3390/ijms252111587

Comments

Article number: 11587

License type

CC BY (attribution alone)