The Deposition of Hydroxyapatite Particles Within an Organic Matrix on the Surface of Poly(lactic acid)
[ 1 ] Instytut Technologii i Inżynierii Chemicznej, Wydział Technologii Chemicznej, Politechnika Poznańska | [ 2 ] Instytut Fizyki, Wydział Inżynierii Materiałowej i Fizyki Technicznej, Politechnika Poznańska | [ 3 ] Instytut Technologii Mechanicznej, Wydział Inżynierii Mechanicznej, Politechnika Poznańska | [ 4 ] Instytut Technologii Materiałów, Wydział Inżynierii Mechanicznej, Politechnika Poznańska | [ P ] pracownik | [ S ] student
[2.5] Inżynieria biomedyczna[2.8] Inżynieria materiałowa[7.6] Nauki chemiczne
2024
artykuł naukowy
angielski
- hydroxyapatite
- poly(lactic acid)
- Langmuir–Blodgett
- implant
- surface modification
EN Hydroxyapatite (HAP) is a well-established material in biomedical applications, especially for bone tissue regeneration, dental implants, and drug delivery systems. Recent research emphasizes enhancing the biocompatibility and osteoconductivity of orthopedic implants using HAP. This study explores the potential of combining HAP with a lipid matrix to improve the surface properties and biocompatibility of poly(lactic acid) (PLA)-based, 3D-printed, resorbable bone implants. We utilized the Langmuir–Blodgett method to deposit HAP within a dihexadecyl phosphate (DHP) matrix onto PLA substrates. This study demonstrates that DHP and HAP form stable monolayers at the air/water interface with HAP particles distributed within a homogeneous lipid matrix. The presence of HAP and the resulting changes in surface free energy (SFE) are hypothesized to enhance the biocompatibility of PLA implants. Our findings indicate that films composed of DHP + HAP 5:1 are particularly effective in altering PLA surface characteristics, potentially improving osteointegration, and reducing microbial adherence. Overall, this work highlights that surface modification of PLA with HAP and lipid matrices is the first step towards new, promising, and cost-effective strategies for developing advanced biomaterials for bone regeneration.
29.10.2024
11587-1 - 11587-13
Article number: 11587
CC BY (uznanie autorstwa)
otwarte czasopismo
ostateczna wersja opublikowana
29.10.2024
w momencie opublikowania
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